The role of C/EBPβin the inflammatory reaction mechanism of neurodegenerative diseases

VernacularTitle:C／EBP β在神经退行性疾病炎症反应机制中的作用
Author: Wang HUI ; Shi JING ; Bian HETAO ; Zhang HAIDONG ; Yan ZHONGRUI
Publication Type:Journal Article
Keywords: CCAAT/enhancer binding proteinβ; Neuron; Neuroinflammation
From: Chinese Journal of Behavioral Medicine and Brain Science 2016;(2):188-192
CountryChina
Language:Chinese
Abstract: To investigate the effect of C/EBP βon the neuroinflammation.Recently,neuroinflamma-tion research mainly focused on C/EBP β,more and more researches indicated that C/EBP βmay play an important role in neurodegenerative diseases.We searched the published papers in PubMed,CNKI,and Wan Fang date bases in June 2015.The key words were used asCCAAT enhancer binding protein beta,Neu-ron,Neuroinflammationand so on.According to the inclusion and exclusion criteria, we summaried and analyzed the literatures.Eventually,42 articles were adapted,most of which were foused on the functions and mechanisms of C/EBP βin neuroinflammation.C/EBP βparticipate in multiple signaling pathways of neu-roinflammation,and the regulation mechanism is complicated.Abrogation of C/EBPβexpression or its down-regulation by gene regulation may may serve as a therapeutic target to attenuate deleterious effects in neural tissue and ultimately prevent the development of neurodegenerative disorders.