Anti-arrhythmic targets of natural products:research advances
10.3867/j.issn.1000-3002.2016.02.010
- VernacularTitle:天然产物抗心律失常作用靶点的研究进展
- Author:
Shengbo YAO
;
Jianhui HAO
;
Xuguang LI
;
Li FAN
;
Yan LIU
- Publication Type:Journal Article
- Keywords:
natural products;
cardiac arrhythmia;
ion channels;
microRNA
- From:
Chinese Journal of Pharmacology and Toxicology
2016;(2):151-157
- CountryChina
- Language:Chinese
-
Abstract:
Cardiac arrhythmia is one of the most common cardiovascular diseases,with high morbidity and mortality,which threatens human health and lives. With the development of medicine, natural products are revealing ever-greater anti-arrhythmic benefits and potential. However,their targets have not been fully clarified. In the recent ten years ,scientists have been studying the molecular mechanisms of natural products that have been found to inhibit INa,ICa-L,Ito,IK1,IKr,IKM3,HERG channel current and steady state K+ current,promote IKs and IKATP,inhibit microRNA-1 expression and change cardiac microRNA expression profile,affect Na+-K+-ATPase and superoxide dismutase activity,inhibitβ receptor and angiotensinⅡ receptor,and regulate lipid metabolism,thus affecting cardiac rhythm and exerting anti-arrhythmic effect. This paper revies the research advances in the antiarrhythmic tar?gets of natural products.
