Role of sphingolipids signaling in pathogenesis of pulmonary fibrosis
10.3867/j.issn.1000-3002.2016.02.011
- VernacularTitle:鞘磷脂类信号通路在肺纤维化发病机制中的作用
- Author:
Jiping YI
;
Ming ZENG
;
Xingxuan HE
- Publication Type:Journal Article
- Keywords:
pulmonary fibrosis;
sphingolipids;
ceramides;
acid ceramidase
- From:
Chinese Journal of Pharmacology and Toxicology
2016;(2):158-164
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis is a group of chronic lung diseases caused by various factors and characterized by chronic inflammations,lung tissue structure damage,increase of pulmonary interstitial collagen and massive deposition of extracellular matrix (ECM). Because of its complicated etiology, there is no effective treatment currently. Recent studies showed that the activation of sphingolipids signaling and pulmonary fibrosis were closely related. This paper describes the composition and function of sphingolipids signaling pathway and its effect on fibrosis in order to provide new ideas about further study of the pathogenesis of pulmonary fibrosis and methods of prevention.
