Progress in alternative testing strategies for human embryonic stem cell-based drug toxicity
10.3867/j.issn.1000-3002.2016.02.013
- VernacularTitle:基于人胚胎干细胞的药物毒性测试替代法研究进展
- Author:
Li JIA
;
Hui PENG
;
Zengming ZHAO
;
Baolier WUHAN
;
Shuangqing PENG
- Publication Type:Journal Article
- Keywords:
embryonic stem cells;
toxicity tests;
preconception injuries;
neurotoxicity;
models,metabolism
- From:
Chinese Journal of Pharmacology and Toxicology
2016;(2):173-177
- CountryChina
- Language:Chinese
-
Abstract:
Traditional drug development and pre-clinical tests are based on animals and involve large numbers of animals,costs and long periods. Meanwhile,inter-species differences are difficult to overcome. Human embryonic stem cells (hESCs),which can self-renew and directly differentiate to types of cells,have become a new tool for toxicity alternative testing. hESC-Based alternative testing models,such as the reproductive toxicity test system,neuro development toxicity test system and metabolic model,can be used to predict target organ toxicity and toxic mechanisms of chemicals, analyze metabolic pathways and to search for potential toxicity biomarkers, when combined with omics such techiniques as metabonomics , proteomics and genomics. Therefore, hESC-based alternative testing models have extensive application to toxicology.
