The associations between human papilloma viruse persistent infection and Stathmin-1 expression and the clinical significance in cervical intraepithelial neoplasia
10.3760/cma.j.issn.1673-4904.2016.01.012
- VernacularTitle:宫颈上皮内瘤变术后人乳头瘤病毒持续感染与 Stathmin-1表达相关性及临床意义
- Author:
Shoufang KONG
;
Teng LYU
;
Hui YUAN
;
Jinyan ZHONG
;
Xuri LI
;
Xuan SUN
;
Shuzhen DAI
- Publication Type:Journal Article
- Keywords:
Recurrence;
Stathmin-1;
Human papilloma viruse;
Cervical intraepithelial neoplasia;
Persistent infection
- From:
Chinese Journal of Postgraduates of Medicine
2016;(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between Stathmin-1 and human papilloma viruse (HPV) persistent infection after conization of uterine cervix, and to show the clinical significance to recurrent of cervical intraepithelial neoplasia (CIN). Methods One hundred and six patients who were treated with conization of uterine cervix for CIN 2-3 grades were enrolled. Thirty-six recurrent patients were enrolled in recurrence group, and the others were enrolled in control group. The expression of Stathmin-1 in primary CIN tissues in two groups was detected by immunohistochemistry. The HPV infection was detected by HPV-DNA test. The relationship of HPV persistent infection and recurrence was analyzed. Results The positive expression rate of HPV persistent infection and HPV persistent infection rate in recurrence group were 88.89%(32/36), 83.33%(30/36), in control group were 34.29%(24/70) and 22.86%(16/70), and there were significant difference (P <0.01). Forty-two patients had HPV persistent infection in 56 patients with stathmin-1 positive expression, and 4 patients had HPV persistent infection in 46 patients Stathmin-1 negative expression. There was positive correlation (r=0.97, P<0.01). The type of HPV persistent infection in two groups was no significant difference (P >0.05). Conclusions Stathmin-1 positive expression is related to HPV persistent infection. The two factors can affect the prognosis of high-grade CIN, and can provide new cues and theory basis for the prevention of recurrence.
