A Case of Postinfectious Glomerulonephritis Following Meningococcal Meningitis.
- Author:
Sung Chul SHIN
1
;
Youn Goo KIM
;
Hyun Jeong BACK
;
Young Hwan LIM
;
Ho Myoung YEO
;
Eung Ho KIM
;
Jung Ah KIM
;
Bang Hoon LEE
;
Woo Heon KANG
;
Beom KIM
;
Wooseong HUH
;
Dae Joong KIM
;
Ha Young OH
;
Ghee Young KWON
Author Information
1. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. ygkim@smc.samsung.co.kr
- Publication Type:Case Report
- Keywords:
Neisseria meningitidis;
Meningitis;
Postinfectious glomerulonephritis;
Complement;
C3 nephritic factor
- MeSH:
Anti-Bacterial Agents;
Azotemia;
Biopsy;
Cerebrospinal Fluid;
Complement C3 Nephritic Factor;
Complement System Proteins;
Diagnosis;
Edema;
Fever;
Glomerulonephritis*;
Headache;
Humans;
Kidney;
Male;
Meningitis;
Meningitis, Meningococcal*;
Neck;
Neisseria meningitidis;
Oliguria;
Proteinuria;
Purpura;
Reference Values;
Young Adult
- From:Korean Journal of Nephrology
2003;22(3):321-325
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 21-year-old male was presented with sudden headache, fever, petechiae and neck stiffness. The diagnosis of meningococcal meningitis was confirmed by examination of cerebrospinal fluid. The clinical symptoms of the illness were improved after treatment of antibiotics. However the patient developed generalized edema, oliguria, azotemia, and heavy proteinuria in the recovery phase of illness. Low serum C3 level was also noted. A kidney biopsy was performed and showed the features of postinfectious glomerulonephritis and typical subepithelial humps on electron-microscopic examination. His symptoms and laboratory findings were improved, and C3 level returned to normal range after conservative treatment. We suggest that a complement deficiency should be ruled out in patients of glomerulonephritis developed during the recovery phase of meningococcal meningitis. C3 nephritic factor detection and renal biopsy should be carefully considered in these patients.
