Receptor-interacting protein activation results in apoptosis,necroptosis and inflammation
10.3760/cma.j.issn.2095-4352.2016.02.020
- VernacularTitle:受体相互作用蛋白对凋亡和坏死性凋亡以及炎症反应的调控机制
- Author:
Yongbing QIAN
;
Ruilan WANG
- Publication Type:Journal Article
- Keywords:
Receptor-interacting protein;
Apoptosis;
Necroptosis;
Inflammatory reaction
- From:
Chinese Critical Care Medicine
2016;(2):184-187
- CountryChina
- Language:Chinese
-
Abstract:
The receptor-interacting protein (RIP) has been identified to play a critical role in necroptosis, which is an inflammatory form of programmed necrosis in trauma, ischemia/reperfusion (I/R), and systemic inflammatory response syndrome (SIRS). Ripoptosome, a newly defined intracellular signaling complex with essential molecule of RIP1, can switch cell death mode between apoptosis and necroptosis. Based on molecular mechanism of RIP-dependent cell death and inflammation, with the understanding of the mechanisms of RIP-dependent apoptosis/necroptosis and its role in inflammation was summed up, and it was found that RIP plays a crucial role in regulating programmed cell death and inflammation. Therefore, further advances in understanding the mechanisms of necroptosis would be important in order to manipulate programmed cell death for therapeutic purposes in I/R injury, trauma, SIRS, and tumor.
