Roles of protein tyrosine phosphatase SHP2 in lung cancer
10.3867/j.issn.1000-3002.2016.01.012
- VernacularTitle:蛋白酪氨酸磷酸酶SHP2在肺癌中作用的研究进展
- Author:
Lingjuan HE
;
Hongqiang CHENG
;
Yuehai KE
;
Linrun WANG
- Publication Type:Journal Article
- Keywords:
lung cancer;
protein tyrosine phosphatase,non receptor type 11;
neoplasm metastasis;
drug resistance,neoplasm
- From:
Chinese Journal of Pharmacology and Toxicology
2016;(1):82-86
- CountryChina
- Language:Chinese
-
Abstract:
The reversible phosphorylation plays an important regulatory role in various pathological and physiological processes. Src Homology 2 domain containing protein tyrosine phosphatase (SHP2),a featured member of the protein tyrosine phosphatase family,is identified as the first PTP proto-oncogene. SHP2 is associated with breast cancer,leukemia,lung cancer,liver cancer,gastric cancer,laryngeal cancer,oral cancer and other types of cancer. Signalling pathways involving SHP2 have also been discovered. It has been recently reported that the high expression of SHP2 in lung cancer regulates cancer cell proliferation,metastasis and drug resistance. SHP2 may be a potential thera?peutic target because it is implicated in many diseases. This article focuses on the research progress in functions of SHP2 in lung cancer.
