Growth and development status of offspring infants born by women with intrahepatic cholestasis of pregnancy after treatment

VernacularTitle:妊娠期肝内胆汁淤积症患者治疗后子代1～2岁生长发育随访研究
Author: Xufen JIANG ; Dexue ZU ; Xuejun DAI
Publication Type:Journal Article
Keywords: Cholestasis,intrahepatic; Pregnancy; Children; Growth and development; Mental retardation
From: Chinese Journal of General Practitioners 2016;(2):144-147
CountryChina
Language:Chinese
Abstract: Ninety six offspring infants (48 males, 48 females) born by hospitalized patients with intrahepatic cholestasis of pregnancy from January 2010 to February 2013 ( study group) and 108 cases of offspring infants (54 males, 54 females) born by hospitalized healthy pregnant woman ( control group) were enrolled in the study. All offspring infants were followed up for 2 years after birth, physical and neuropsychological development parameters were investigated at 1 month, 1 year and 2 years after birth. There were no significant difference in body weight [ ( 11.94 ±0.89 ) vs.( 13.99 ±0.78 ) kg ] , length [(86.2 ±2.0) vs.(87.0 ±3.1) cm], sitting height, [(51.8 ±2.1) vs.(51.8 ±1.9) cm], head circumference[(47.9 ±1.3) vs.(48.1 ±1.1) cm], development of intelligence quotient index[(99.4 ± 12.9) vs.(100.0 ±12.0)] at 2 years after birth between two groups (P>0.05).Two-year follow up reveals that ursodeoxycholic acid and S-adenosine methionine treatment for women with intrahepatic cholestasis of pregnant has no significant adverse effect on the growth and development of their offspring.