Aromatase inhibitor(letrozole) is effective in activating the function of hypothalamus-pituitary-gonad axis in male patients with partial idiopathic hypogonadotropic hypogonadism

VernacularTitle:芳香化酶抑制剂（来曲唑）可有效治疗男性部分性特发性低促性腺激素性性腺功能减退症
Author: Zhaoxiang LIU ; Jangfeng MAO ; Xueyan WU ; Xi WANG ; Bingkun HUANG ; Junjie ZHENG
Publication Type:Journal Article
Keywords: Aromatase inhibitor; Idiopathic hypogonadotropic hypogonadism; Treatment
From: Chinese Journal of Endocrinology and Metabolism 2016;(2):125-127
CountryChina
Language:Chinese
Abstract: [Summary] Eighteen patients with idiopathic hypogonadotropic hypogonadism( IHH) receiving aromatase-inhibitor( AI) letrozole for at least 3 months were recruited.After 3 months′treatment, LH levels were increased from (2.1 ±1.5) IU/L to (3.6 ±3.7) IU/L(P=0.029), and FSH levels from (2.6 ±1.8) IU/L to (4.3 ±3.4) IU/L (P=0.003).Total testosterol was increased from (87 ±42) ng/dl to (166 ±200) ng/dl(P=0.082), and estradiol wasdecreasedfrom(22.7±18.7) pg/ml to (13.4±10.6) pg/ml(P=0.020).The average testis volume was increased[(14.3 ±3.9 vs 11.2 ±4.9) ml, P<0.01].Sperms were detected in 8 out of 9 patients who did seminal fluid test.The result of general linear model showed that LH(60 min) was significantly related with total testosterol increment( P=0.045) .