Observation of the efficacy and toxicity of docetaxel plus cisplatin and 5 -Fluorouracil plus cisplatin in the treatment of metastatic esophageal cancer
10.3760/cma.j.issn.1008-6706.2015.s2.008
- VernacularTitle:FP 方案与 DP 方案治疗转移性食管癌的临床疗效及毒性反应观察
- Author:
Yidong MA
;
Li ZHANG
;
Yonghong QIAN
- Publication Type:Journal Article
- Keywords:
Esophageal Neoplasms;
Fluorouracil;
cisplatin;
Docetaxel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(z2):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the efficacy and toxicity of 5 -Fluorouracil plus cisplatin (FP)and docetaxel plus cisplatin(DP)in the treatment of patients with metastatic esophageal cancer.Methods A total num-ber of 68 cases of metastatic esophageal cancer confirmed by histopathology and (or)cytological examination was ana-lyzed retrospectively.There were 33 cases in FP group(5 -Fu 500mg/m2 ,d1 -5;DDP 20mg/m2 ,d1 -5,28 days a cycle),and 35 cases were in DP group(DTX 75mg/m2 ,d1,DDP 20mg/m2 ,d1 -3,21 days a cycle).The evaluation of efficacy and toxicity were performed on all patients per 2 cycles.Statistics and analysis of the difference between the two groups was performed.Results For FP group,CR was in 1 case,PR ere in 12 cases,SD ere in 16 cases and PD ere in 4 cases,respectively.The corresponding value was 3,18,11 and 3 for DP group.The objective response rate (ORR)for DP group(68.57%)was significantly higher than FP group(36.39%)(χ2 =5.83,P =0.02),and the disease control rate (DCR)were similar with no significance between the two groups(P =0.71).The Ⅲ -Ⅳ degree myelotoxicity for DP group was higher than for FP group with statistical difference (χ2 =7.07,P =0.01),while the incidence of nausea,vomiting,diarrhea and liver toxicity was similar (P >0.05).Conclusion DP regimen was more effective than FP regimen for the metastatic esophageal cancer,and the patients can tolerate with the slightly higher incidence of myelotoxicity,it was worthy of further study and clinical application.
