Dynamic Contrast-enhanced MRI with Tofts Model in Relapsing-remitting Multiple Sclerosis
10.3969/j.issn.1005-5185.2015.12.004
- VernacularTitle:动态对比增强MRI Tofts模型在复发-缓解型多发性硬化中的应用
- Author:
Ping YIN
;
Yi LIU
;
Jinru ZHOU
;
Xiaoqing SHI
;
Chun ZENG
;
Jingjie WANG
;
Yongmei LI
- Publication Type:Journal Article
- Keywords:
Multiple sclerosis;
Magnetic resonance imaging;
Image enhancement;
Perfusion imaging;
Microcirculation;
Hemodynamics
- From:
Chinese Journal of Medical Imaging
2015;(12):892-895
- CountryChina
- Language:Chinese
-
Abstract:
PurposeMultiple sclerosis (MS) is characterized by time and spatial multiple, and it is the main reason for disabled young people. This paper aims to investigate the application of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with dual-compartment Tofts model in relapsing-remitting multiple sclerosis (RRMS) and its correlation with clinical scoring.Materials and MethodsThe clinical data of 25 patients with RRMS were retrospectively studied. The patients underwent the conventional MRI and the DCE-MRI examination. The result was processed by dual-compartment Tofts model and quantitative measurement was carried out in terms of volume transfer constant (Ktrans), rate constant between EES and blood plasma (Kep) and the volume of EES per unit volume of tissue (Ve), cerebral blood flow (CBF) and cerebral blood volume (CBV) of the lesions and normal-appearing white matter (NAWM) regions. The correlation between imaging biomarkers, expanded disability states scale (EDSS) and disease duration were also analyzed.Results ① The differences of MR imaging biomarkers Ktrans and Kep were significant between the regions of nonenhancing (NE) lesions, the NAWM regions near NE lesions and the NAWM regions far from NE lesions (χ2=6.777 and 22.343,P<0.05); however, Ve in the NE lesions had no significant differences compared with that in the NAWM regions near and far from NE lesions (P>0.05).②The CBF and CBV among these three groups had no signiifcant differences (P>0.05).③The CBF of NE lesions was signiifcantly correlated with disease duration (r=0.518,P<0.05);however, the other markers like Ktrans, Kep, Ve, CBF and CBV were neither signiifcantly correlated with EDSS nor with disease duration (r=-0.371-0.052,P>0.05).Conclusion DCE-MRI with Tofts model can quantitatively measure microvascular permeability and perfusion characteristics of lesions and NAWM regions, which thus reflects hemodynamic changes in patients with multiple sclerosis.
