Express of TIM-3 and Galectin-9 Genes in Peripheral Blood Mononuclear Cells from Patients with Asthma
10.3969/j.issn.1671-7414.2016.01.014
- VernacularTitle:哮喘患者外周血单个核细胞 TIM-3及 Galectin-9的表达与临床意义
- Author:
Tao LIANG
;
Yang ZHANG
;
Yiting XU
;
Ning WANG
;
Pengcheng CAI
;
Xiaobei WANG
;
Lihua HU
- Publication Type:Journal Article
- Keywords:
asthma;
TIM-3;
galectin-9
- From:
Journal of Modern Laboratory Medicine
2016;(1):52-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of the mRNA expression of TIM-3 and Galectin-9 in peripheral blood mono-cytes (PBMCs)of acute exacerbation asthma patients and their clinical significances.Methods 60 patients with acute exac-erbation asthma (eliminating 15 cases of non-conform to the regulations)and 30 cases of healthy subjects were collected from January to October of 2014.Used fluorescence quantitative real-time reverse transcription-polymerase chain reaction to measure the mRNA expression of TIM-3 and Galectin-9 in PBMCs of patients with asthma and healthy controls.Results The expression of TIM-3,Galectin-9 and IFN-γmRNA in the PBMCs from acute exacerbation asthma patients were all ab-normally higher than healthy controls (U =458.5,P =0.019;U =437.5,P =0.010;U =260,P <0.001).There were statis-tically significant differences between them.Conclusion TIM-3/Galectin-9 pathway may participate in the occurrence,devel-opment of asthma.TIM-3 or (and)Galectin-9 may prove to be an important target for treatments to asthma.
