The relationship of apolipoprotein E allelic frequency and serum lipid levels in patients with Alzheimer′s disease
10.3969/j.issn.1006-5725.2016.01.041
- VernacularTitle:阿尔茨海默病患者ApoE等位基因频率与脂类代谢的相关性
- Author:
Ting ZHANG
;
Guoyan HU
;
Yulong LIN
- Publication Type:Journal Article
- Keywords:
Alzheimer′s disease;
Apolipoprotein E;
Polymorphism;
DNA microarray
- From:
The Journal of Practical Medicine
2016;32(1):127-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of apolipoprotein E (ApoE) allelic frequency and serum lipid levels in patients with Alzheimer′s disease (AD). Methods DNA microarray was used to detect the ApoE genotypes of AD patients (n = 200) and age-matched non-demented elderly control subjects (n = 159). Serum lipid levels was measured by Immunoturbidimetric assay at the same time. We analyzed the ApoE genotype distribution and the relationship of apolipoprotein E ( ApoE ) allelic frequency and serum lipid levels . Results The ApoE ε4 allelic frequencies (25.5%) in AD group is higher than that of the control group (7.9%) (P < 0.05). The ε2 allele was associated with a higher ApoE concentration, whereas with a mediate concentration in ε3 and the lowest concentration ( P < 0 . 05 ) in ε4 . Serum concentrations of ApoE showed no significant difference between AD patients and the healthy population who were with the same genotype (P > 0.05). Conclusion The ApoE levels are negatively related to ApoE ε4 allele frequency and have no significant differences with the same genotype in AD and the control group,which suggests that lower serum ApoE levels in AD patients is caused by higher ApoE ε4 allelic frequency in AD than in healthy population.
