The diagnostic value in bronchoalveolar lavage galactomannan antigen detection of invasive pulmonary aspergillosis in patients without granulocyte deficiency
10.3969/j.issn.1006-5725.2016.01.042
- VernacularTitle:支气管肺泡灌洗液半乳甘露聚糖抗原检测对非粒细胞缺乏患者的侵袭性肺曲霉病诊断价值
- Author:
Qingling GUO
;
Yubiao GUO
;
Kang LIAO
;
Zhiwen ZHU
- Publication Type:Journal Article
- Keywords:
Bronchoalveolar lavage fluid;
Galactomannan antigen;
Invasive pulmonary aspergillosis;
Deficiency of granulocyte.
- From:
The Journal of Practical Medicine
2016;32(1):130-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study infection of the lung tissue by bronchoalveolar lavage for BALF and explore whether GM can help improve the he diagnosis efficiency in patients without granulocyte deficiency with IPA, and find the threshold of GM values. Methods Between January 2011 and December 2011, 173 cases of patients were considered possible invasive pulmonary aspergillosis in parallel BALF GM detection in the center of the respiratory endoscopic examination.. According to the diagnostic criteria at home and abroad, all the cases were divided into four groups, including group of IPA, group of tuberculosis, group of bacterial pneumonia and group of non-infection. Using ELISA method for determination of serum and BALF GM. The diagnostic value was made by statistical methods in BALF GM detection without patients of granulocyte deficiency with IPA. Results There were 11 cases in the group of IPA, 23 cases in the group of tuberculosis, 90 cases in the group of bacterial pneumonia and 49 cases in the group of non-infection. In patients without granulocyte deficiency with IPA,BALF GM value was higher comparing with the patients without IPA. There were significant difference between the two groups; Comparing the GM value in the serum, the detection of BALF GM was higher in IPA. ROC curve analysis found that when the BALF GM test value was 0.95 or higher, there was highest possible with IPA. Conclusion BALF GM testing is beneficial to patients of invasive pulmonary aspergillosis without granulocyte deficiency in early identification with IPA. This study found that BALF GM best value is 0.95 or higher.
