XRCC1 rs25487 locus genetic polymorphisms and susceptibility to nonobstructive azoospermia in Hui minority ethnic population of Shaanxi province
10.7652/jdyxb201602022
- VernacularTitle:XRCC1基因 rs25487位点多态性与陕西回族男性人群非梗阻性无精症的相关性
- Author:
Jian ZHANG
;
Huihui HONG
;
Shuiping HAN
;
Wenbao ZHAO
;
Liang ZHOU
;
Dangxia ZHOU
;
Hecheng LI
- Publication Type:Journal Article
- Keywords:
X-ray repair cross-complementing group 1 (XRCC1)gene;
nonobstructive azoospermia;
gene pol-ymorphism;
PCR-RFLP
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2016;(2):256-259
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between X-ray repair cross complementing group 1 (XRCC1)gene rs25487 locus polymorphisms and nonobstructive azoospermia in Hui minority ethic population of Shaanxi Province.Methods We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)method for genotyping at XRCC1 gene rs25487 locus in 79 patients with nonobstructive azoospermia and 82 healthy male controls in Hui minority ethic population of Shaanxi Province.Then we analyzed the association be-tween XRCC1 gene rs25487 locus and nonobstructive azoospermia.Results Compared with GG genotype,GA, AA and GA + AA genotypes demonstrated a significantly increased risk for nonobstructive azoospermia (OR =2.286,95% CI 1.1 5 1-4.539;OR =2.202,95% CI 0.753-6.439;OR =2.271,95% CI 1.1 71-4.403),respec-tively.Meanwhile,the A allele frequency was significantly higher in azoospermic patients than in controls (OR =1.582,95% CI 1.005-2.492,P =0.047).Conclusion G→A in XRCC1 gene rs25487 locus is correlated with nonobstructive azoospermia in Hui minority ethic population of Shaanxi province.
