Expression and Clinical Relations of PTPRD in Esophageal Squamous Cell Carcinoma
10.3969/j.issn.1671-7414.2016.01.001
- VernacularTitle:蛋白酪氨酸磷酸酶受体 D（PTPRD）在食管鳞状细胞癌组织中的表达及其临床意义
- Author:
Shanqu LI
;
Miao LAN
;
Renli ZHAO
;
Bo YANG
;
Li GONG
;
Xiujuan HAN
;
Li YAO
;
Shaojun ZHU
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
PTPRD;
esophageal squamous cell carcinoma(ESCC);
immunohistochemistry;
prognosis
- From:
Journal of Modern Laboratory Medicine
2016;(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the expression of PTPRD in esophageal squamous cell carcinoma (ESCC)and analyze its correlation with pathological features and patient survival.Methods Immunohistochemistry analysis was applied to detect the expression level and location of PTPRD in 236 patients with ESCC.Clinical and pathological features were collected and a 5 years’follow-up after surgery were performed.Results Statistic analysis showed that expression of PTPRD in ESCC was lower than in normal esophageal epithelial cells (22.0% vs 57.2%,P =0.000).The expression of PTPRD was correla-ted to the differentiation grade,depth of tumor invasion and lymph nodes metastasis.The expression of PTPRD was higher in group with well differentiation,less invasion depth and no lymph node metastasis (P =0.013,0.025,0.019).The expres-sion of PTPRD was not correlated to age or gender (P =0.170,0.787).The survival analysis showed that thegroup with more PTPRD expression had better prognosis.Conclusion PTPRD was correlated to progression and prognosis of ESCC.It may be a new potential tumor suppressor gene of ESCC,and its expression level might may a useful marker for predicting prognosis for ESCC patients.
