Association of Interleukin-6 Gene-174C/G and-572C/G Polymorphisms with Hypertension:A Meta-Analysis

VernacularTitle:白细胞介素6-174C／G 及-572C／G 基因多态性与高血压相关性 meta 分析
Author: Yangmin ZHANG ; Feixiao XUE
Publication Type:Journal Article
Keywords: interleukin-6; gene polymorphisms; hypertension; meta-analysis
From: Journal of Modern Laboratory Medicine 2016;(1):33-37
CountryChina
Language:Chinese
Abstract: Objective To assess the association of interleukin-6 (IL-6)-174C/G and-572C/G gene polymorphisms with hy-pertension risk.Methods The electronic databases,such as Pubmed,Web of Science,Google scholar,China National Knowl-edge Infrastrure and Wanfang database were searched by the interleukin-6,polymorphism,IL-6,hypertension,high blood pressure as the keywords/abstract.Random effect model was used to calculate the pooled odds ratio.Results The meta-a-nalysis included 6 studies with 1 041 hypertension cases and 1 088 health subjects,which was no significant association be-tween IL-6-174C/G gene polymorphism and hypertension (C vs G:OR=0.50,95%CI=0.22~ 1.14,P =0.10),and in the stratified analysis by ethnicity,no significant was found in Asian subgroup (C vs G:OR=0.75,95%CI=0.41~1.38,P =0.36).There was also no association between IL-6-572C/G gene polymorphism and hypertension in Asian (C vs G:OR =0.76,95%CI=0.51~1.15,P =0.20).Conclusion The IL-6-174C/G and-572C/G gene polymorphisms were suggested to be no related to the increased risk of hypertension in Asian.