Expression and significance of Nanog and Oct4 in endometriosis and adenomyosis
10.3969/j.issn.1006-5725.2016.01.018
- VernacularTitle:Nanog和Oct4在子宫内膜异位性疾病中的表达及意义
- Author:
Wenjuan CAI
;
Liping GUO
;
Lijiao ZHENG
;
Liting WANG
;
Jingkun YE
;
Ying MA
- Publication Type:Journal Article
- Keywords:
Nanog;
Oct4;
Endometriosis and adenomyosis
- From:
The Journal of Practical Medicine
2016;32(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Nanog and Oct4 (stem cell transcription factors) in endometriosis and adenomyosis, and to explore their potential functions in the development of endometriosis and adenomyosis. Methods The expressions of Nanog and Oct4 in the ectopic and eutopic endometrium of 50 patients with endometriosis and/or adenomyosis (ectopic endometrium group and eutopic endometrium group), and 21 patients free from endometriosis and adenomyosis (control group) were detected by immunohistochemical SABC methods. Statistical analysis was conducted for the correlation between the expressions of Nanog and Oct4 based on patients′ clinical pathological parameters. Results Nanog and Oct4 protein expressions in ectopic endometrium group were higher than that in control group (P<0.01);the expressions of Nanog and Oct4 in eutopic endometrium group and control group showed no significance (P > 0.05); there was positive correlation between the expressions of Nanog and Oct4 in ectopic endometrium group (r = 0.590, P < 0.01). Conclusion Nanog and Oct4 present high expression in eutopic and ectopic endometrium , which may play a important role in the development of endometriosis and adenomyosis.
