Expression and signification of microRNA-31 in the plasma of esophageal squamous cell carcinoma of Xinjiang Kazak and Han nationality patients
10.3969/j.issn.1006-5725.2016.01.019
- VernacularTitle:新疆哈萨克族与汉族食管鳞癌患者血浆中microRNA-31的表达及其意义
- Author:
Guijun SHI
;
Xue KANG
;
Yong ZHENG
;
Yanzhi HAN
;
Ning ZHANG
;
Cuihua QI
;
Weigang CHEN
- Publication Type:Journal Article
- Keywords:
Esophageal squamous cell carcinoma;
miR-31;
Oncogene
- From:
The Journal of Practical Medicine
2016;32(1):61-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between miR-31 and ESCC in expression of miR-31 in the plasma of ESCC in Xinjiang Kazak and Han nationality patients. Methods The plasma samples were collected respectively from patients with ESCC in 20 cases and healthy subjects in 20 cases. The relatively expression of miR-31 was detected by real-time Q-PCR. Results The expression of miR-31 with ESCC were higher than those of the normal control group, which related to the degree of tumor differentiation in Kazak ESCC patients (P < 0.01); the levels of miR-31 relative expression in Kazak were higher than that of Han (P = 0.008, P = 0.027). Conclusion miR-31 may be involved in the occurrence of ESCC in Han and Kazak nationality. miR-31 might be another risk factor in high incidence of ESCC in Kazak than Han nationality.
