Correlation between Nutritional Megaloblastic Anemia and Homocysteine in Shenzhen
10.3969/j.issn.1671-7414.2016.01.024
- VernacularTitle:深圳地区营养性巨幼细胞性贫血与同型半胱氨酸水平的相关性研究
- Author:
Taojun HE
;
Jie ZHAO
;
Yuxue WANG
;
Qiaoyun DAN
;
Hongyuan JIANG
;
Fan MO
- Publication Type:Journal Article
- Keywords:
nutritional megaloblastic anemia;
homocysteine;
folic acid;
vitamin B12
- From:
Journal of Modern Laboratory Medicine
2016;(1):83-85
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the correlation between nutritional megaloblastic anemia and homocysteine,in order that e-valuate the application of homocysteine in some aspects that detection and treatment of megaloblatic anemia.Methods The study was divided into three groups,included case group (MA group,n=192,including megaloblatic anemia of vitamin B12 deficiency,n=60;megaloblatic anemia of folic acid deficiency,n=69;megaloblatic anemia of folic acid and vitamin B12 defi-ciency,n=63),matched group (heathy persons,n=200)and treated group (persons who recovered from megaloblatic ane-mia,n=192).Results The difference on homolevel in plasma between case group and matched group had statistical sidnifi-cance (t=3.56,3.21,2.78,P <0.01).The difference on homocysteine level in plasma between treated group and matched group had no statistical sidnificance (t=1.23,0.98,0.77,P >0.05).The Hcy levels of folic acid deficiency vitamin B12 de-ficiency,vitamin B12 deficiency and folic acid and vitamin B12 deficiency had no statistical sidnificance (t=1.42,P >0.05). Conclusion The homocysteine level of patients who had nutritional megaloblatic anemia higher than heathy persons.High level of homocysteine had correction between the nutritional megaloblatic anemia.The lack of some nutrition facters (eg:fo-lic acid,vitamin B12)can lead to high homocysteine disease.Detecting the change of homocysteine level in plasma can guide the treatment of nutritional megaloblatic anemia.
