Diagnostic Value of Thirteen Types of Serum Tumor Markers for Lung Cancer in China:A Meta-Analysis
10.3969/j.issn.1671-7414.2016.01.028
- VernacularTitle:国内13种血清肿瘤标志物对肺癌诊断价值的 Meta 分析
- Author:
Ying PENG
;
Zhenghua DENG
;
Xianyong WEN
- Publication Type:Journal Article
- Keywords:
lung cancer;
tumor bio-marker;
Meta analysis
- From:
Journal of Modern Laboratory Medicine
2016;(1):96-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate diagnostic values of thirteen single and combined serum tumor markers in the diagnosis of lung cancer in Chinese people.Methods Chinese databases were searched systematically for prospective studies of serum tumor markers in Chinese patients with lung cancer and standard statistical methods for meta-analysis were applied.Results Thirty articles were selected containing thirteen types of molecular tumor markers and 4 393 people.The optimal serum marker was CEA+CA125+CYFRA21-1 with the combined sensitivity,specificity,positive likelihood ratio,negative likeli-hood ratio,the diagnostic odds ratio and the area under the summary receiver operating characteristic curve (AUC)was 87%[95% confidence interval (CI)0.81~0.91],93%(95% CI 0.89~0.95),11.8 (95% CI 7.84~17.7),0.15 (95% CI 0.10~0.21),81.3(95% CI 44.4~149.0)and 0.910,respectively.Conclusion There was improved diagnostic performance in combined markers than other individuals.Serum tumor marker CEA+CA125+CYFRA21-1 is the optimal biomarker for the diagnosis of lung cancer.
