Association of gene polymorphism of signal transducer and activator of transcription 3 with rheumatoid arthritis in the Chinese Han population
10.3969/j.issn.2095-4344.2016.02.016
- VernacularTitle:信号传导和转录活化因子3基因单核苷酸多态性与中国汉族人类风湿关节炎的相关性
- Author:
Qingyun XIE
;
Meng WEI
;
Peiliang FU
;
Jiuyi SUN
;
Qirong QIAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;(2):242-247
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Signal transducer and activator of transcription 3 (STAT3) is an important cytokine signaling pathway, which plays an important role in inflammatory diseases. However, it is unclear whether gene polymorphism of STAT3 is associated with rheumatoid arthritis in the Chinese Han population. OBJECTIVE: To explore the association of gene polymorphism of STAT3 with rheumatoid arthritis in the Chinese Han population. METHODS:Four tag-single-nucleotide polymorphisms (tag-SNPs) in STAT3 were selected from the Chinese Han population of HapMap database. The study was performed with 228 rheumatoid arthritis cases and 228 normal controls. Four tag-SNPs (rs12601982, rs2293152, rs8078731 and rs9912773) were examined by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. RESULTS AND CONCLUSION:The frequency of GG genotype at rs9912773 was 18.9% and 10.5% respectively in rheumatoid arthritis and control groups, and there was a significant difference between the two groups (P < 0.05). These results indicate the possible association between the STAT3 gene polymorphism at rs9912773 and the susceptibility of rheumatoid arthritis in the Chinese Han population.
