The Effect of Dialysis Membrane Flux on Amino Acid Loss in Hemodialysis Patients.
10.3346/jkms.2007.22.4.598
- Author:
Hyo Wook GIL
1
;
Jong Oh YANG
;
Eun Young LEE
;
Eun Mi LEE
;
Jong Soon CHOI
;
Sae Yong HONG
Author Information
1. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. eylee@sch.ac.kr
- Publication Type:Original Article ; Clinical Trial
- Keywords:
Amino Acid;
High Flux Membrane;
Low Flux Membrane
- MeSH:
Adult;
Aged;
Amino Acids/*blood/chemistry;
Bicarbonates/blood;
Blood Urea Nitrogen;
Chromatography, High Pressure Liquid;
Creatine/blood;
Dialysis Solutions/analysis;
Female;
Humans;
Male;
*Membranes, Artificial;
Middle Aged;
Potassium/blood;
Renal Dialysis/*instrumentation;
Sodium/blood
- From:Journal of Korean Medical Science
2007;22(4):598-603
- CountryRepublic of Korea
- Language:English
-
Abstract:
We examined whether high flux membranes (HF) may induce a greater loss of amino acids compared to low flux membranes (LF). Ten hemodialysis patients participated in this study. Pre- and post-hemodialysis plasma amino acid profiles were measured by reverse-phase high pressure liquid chromatography for both HF and LF. We measured the dialysate amino acid losses during hemodialysis. The reduction difference for plasma total amino acid (TAA), essential amino acid (EAA), and branch chained amino acid (BCAA) was not significantly different in comparisons between the two membranes. (HF vs. LF; TAA 66.85+/-30.56 vs. 53.78+/-41.28, p=0.12; EAA 14.79+/-17.16 vs. 17.97+/-28.69, p=0.12; BCAA 2.21+/-6.08 vs. 4.16+/-10.98 mg/L, p=0.13). For the HF, the reduction in plasma amino acid levels for TAA and EAA were statistically significant. Although it was not statistically significant, the dialysate losses of BCAA were greater than the reduction in plasma (plasma reduction vs. dialysate loss; HF 2.21+/-6.08 vs. 6.58+/-4.32, LF 4.16+/-10.98 vs. 7.96+/-3.25 mg/L). HF with large pores and a sieving coefficient do not influence dialysate amino acid losses. Hemodialysis itself may influence the dialysate amino acid losses and may have an effect on protein metabolism.
