Expression and clinical significance of Wnt2 and Dvl protein in esophageal aquamous carcinoma
10.11958/20150007
- VernacularTitle:Wnt2与Dvl蛋白在食管鳞癌组织中的表达及临床意义
- Author:
Yongtao WANG
;
Hongjiang WANG
;
Xingming WANG
;
Xue FENG
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
carcinoma;
squamous cell;
Wnt2 protein;
Dvl protein;
blotting;
Western
- From:
Tianjin Medical Journal
2016;44(2):210-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expressions of Wnt2 and dishevelled (Dvl) protein in esophageal squamous carci-noma, and analyze their relationship with the occurrence and development of esophageal squamous cell carcinoma. Meth-ods The expression levels of Wnt2 and Dvl protein were detected by Western blot assay in 60 samples of esophageal carci-noma and adjacent non-carcinomatous esophageal tissues, and their relationship with clinical pathological features were ana-lyzed. Results The relative expression levels of Wnt2 and Dvl protein were higher in esophageal squamous carcinoma tis-sue (0.512 ± 0.406, 1.218±1.082) than those of esophageal tissue adjacent to carcinoma (0.153 ± 0.189, 0.505±0.358). There were significant differences in the expression levels of Wnt2 and Dvl protein between different infiltration depth, different TNM stages, and lymph node metastasis (P<0.01). There was a positive correlation between Wnt2 and Dvl protein in esopha-geal squamous carcinoma (r=0.718, P<0.01). Conclusion The high expression levels of Wnt2 and Dvl protein promote the development and metastasis of esophageal squamous cell carcinomas collaboratively via Wnt2 signal transduction path-ways.
