Research progress of MicroRNAs involved in the tumor microenvironment regulation in non-cell-autonomous mechanisms
10.11958/59124
- VernacularTitle:miRNAs以非细胞自主机制参与肿瘤微环境调节的研究进展
- Author:
Jinman GUO
;
Chao TAN
;
Huojun HU
;
Yuan TAN
- Publication Type:Journal Article
- Keywords:
microRNAs;
tumor;
microenvironment;
non-cell-autonomous function;
gene expression regulation;
immu-nity;
cellular;
review
- From:
Tianjin Medical Journal
2016;44(2):247-250
- CountryChina
- Language:Chinese
-
Abstract:
As an internal environment of tumor occurrence, tumor microenvironment is composed of a variety of cells and extracellular matrix, and plays a crucial role in tumor formation, transfer and resistance to drugs. The regulation of tumor microenvironment will be a potential target to control the cancer. MicroRNAs (miRNAs) are a kind of 21 to 25 nucleotides single-stranded RNA, and are mainly involved in regulating gene expression. Recently, with the suggestion of cellular auton-omous tumor inhibition mechanism, the regulation of tumor microenvironment by miRNAs has received great attention. This review summarizes recent findings on the non-cell-autonomous mechanisms of miRNAs-mediated regulation of tumor micro-environments, which provides foundations and perspective on the design of therapeutic interventions.
