FoxOs and osteoporosis
10.3969/j.issn.1001-1978.2016.02.005
- VernacularTitle:FoxOs与骨质疏松
- Author:
Jin LI
;
Yajun YANG
;
Yuyu LIU
- Publication Type:Journal Article
- Keywords:
FoxOs;
osteoporosis;
oxidative stress;
reactive oxygen species ( ROS );
pathological mechanism;
therapeutic strategy
- From:
Chinese Pharmacological Bulletin
2016;(2):169-171
- CountryChina
- Language:Chinese
-
Abstract:
As one subclass of forkhead proteins, the forkhead box O ( FoxO) transcription factors take part in a series of bio-logical processes including cellular apoptosis, damaged DNA re-pair and cleavage of reactive oxygen species(ROS). Increasing evidence highlights that oxidative stress elicited by FoxOs con-tributes to imbalance of redox status in cells related to bone me-tabolism, resulting in development of the pathogenesis of osteo-porosis. This article reviews the relationship of FoxOs and osteo-porosis, which may be beneficial for the research of pathological mechanism and therapeutic strategy of osteoporosis.
