Progress on pharmacokinetic studies of therapeutic monoclonal antibodies
10.3969/j.issn.1001-1978.2016.02.006
- VernacularTitle:单克隆抗体药物的药代动力学研究进展
- Author:
Jianjun GUO
;
Lili WANG
;
Qi ZHANG
;
Aobo ZHANG
;
Jing ZHU
;
Yongyue ZHAO
;
Bingxu ZHANG
;
Haizhi BU
- Publication Type:Journal Article
- Keywords:
monoclonal antibody;
pharmacokinetics;
absorp-tion;
distribution;
elimination;
prediction of human pharmacoki-netics
- From:
Chinese Pharmacological Bulletin
2016;(2):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Monoclonal antibody ( mAb ) represents a class of therapeutics experienced dramatic development over the past 30 years. Because of the tremendous differences in physicochemical and biological properties between mAbs and small molecules, the mAb therapeutics significantly differ from the chemical drugs in pharmacokinetic characteristics and underlying mechanisms. Full understanding of those characteristics and mechanisms may efficiently guide the screening and development of mAb medi-cines, and would well support their safety evaluation and clinical dosage regimen designing. This review is to summarize pharma-cokinetics and underlying mechanisms of mAbs from the aspects of absorption, distribution and elimination, as well as the ap-proaches for prediction of mAb pharmacokinetics in humans.
