Diagnostic Value of Galectin-3, HBME-1, Cytokeratin 19, High Molecular Weight Cytokeratin, Cyclin D1 and p27(kip1) in the Differential Diagnosis of Thyroid Nodules.
10.3346/jkms.2007.22.4.621
- Author:
Young Joo PARK
1
;
Soo Heon KWAK
;
Dong Chul KIM
;
Haeryoung KIM
;
Gheeyoung CHOE
;
Do Joon PARK
;
Hak Chul JANG
;
Seong Hoe PARK
;
Bo Youn CHO
;
So Yeon PARK
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Thyroid Neoplasm;
Papillary Carcinoma;
Follicular Carcinoma;
Galectin 3;
HBME-1;
Cytokeratin 19
- MeSH:
Adenocarcinoma, Follicular/diagnosis/metabolism;
Carcinoma, Papillary, Follicular/diagnosis/metabolism;
Cyclin D1/analysis;
Cyclin-Dependent Kinase Inhibitor p27/analysis;
Diagnosis, Differential;
Galectin 3/analysis;
Humans;
Immunohistochemistry;
Intracellular Signaling Peptides and Proteins/analysis;
Keratin-19/analysis;
Keratins/analysis;
Sensitivity and Specificity;
Thyroid Gland/chemistry/*pathology;
Thyroid Nodule/*diagnosis/metabolism;
Tumor Markers, Biological/*analysis
- From:Journal of Korean Medical Science
2007;22(4):621-628
- CountryRepublic of Korea
- Language:English
-
Abstract:
The distinction between benign and malignant thyroid tumors is critical for the management of patients with thyroid nodules. We applied immunohistochemical staining for galectin-3, HBME-1, cytokeratin 19 (CK19), high molecular weight cytokeratin (HMWCK), cyclin D1 and p27(kip1) in 295 thyroid lesions to determine their diagnostic accuracy. The expression of all markers was significantly associated with differentiated thyroid carcinoma (DTC).The sensitivity for the diagnosis of DTC was 94.7% with galectin-3, 91.3% with HBME-1, and 90.3% with CK19. The specificities of these markers were 95.5%, 69.7%, and 83.1%, respectively. Combining these markers, co-expression of galectin-3 and CK19 or galectin-3 and HBME-1 was seen in 93.2% of carcinomas but in none of the benign nodules. Comparing follicular variant of papillary carcinoma (FVPC) with follicular carcinoma (FC), the expression of galectin-3, CK19, and HMWCK was significantly higher in FVPC. When comparing FC with FA, the expression of galectin-3 and HBME-1 was significantly higher in FC. These results suggest that 1) galectin-3 is a useful marker in the distinction between benign and malignant thyroid tumors, 2) the combined use of HBME-1 and CK19 can increase the diagnostic accuracy, and 3) the use of CK19 and HMWCK can aid in the differential diagnosis between PC and FC.
