Effects of combination treatment with SAHA and TRAIL on ER positive breast cancer cell MCF-7
10.3969/j.issn.1001-1978.2016.02.015
- VernacularTitle:SAHA和TRAIL联合使用对乳腺癌雌激素受体阳性细胞MCF-7生长的影响
- Author:
Han HAN
;
Min WANG
- Publication Type:Journal Article
- Keywords:
SAHA;
TRAIL;
breast cancer;
ER posi-tive;
MCF-7 cell;
synergistic effects
- From:
Chinese Pharmacological Bulletin
2016;(2):223-228
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of com-bined treatment of SAHA and TRAIL on human breast cancer ER positive cell line MCF-7 . Methods MCF-7 cells were treated with SAHA and/or TRAIL. The inhibitory rates were detected by real-time cell prolifer-ation assays. Morphology changes of MCF-7 cells were observed through time-lapse live cell imaging acquisi-tion. Results Real-time cell proliferation assays showed that the anti-tumor efficacy of SAHA was sig-nificantly enhanced in combination with TRAIL. The results of time-lapse live cell imaging acquisition dem-onstrated that, with treatment of SAHA and TRAIL, the growth inhibition of MCF-7 cells was more obvious than that of in TRAIL or SAHA treatment alone. Con-clusion The combination treatment of SAHA and TRAIL has a synergistic effect of growth inhibition on breast cancer MCF-7 cells.
