Clinical Effects of Gamma Globulin at Different Doses Combined with Dexamethasone in the Treatment of Children with Severe Idiopathic Thrombocytopenic Purpura
- VernacularTitle:不同剂量丙种球蛋白联合地塞米松治疗小儿中重症特发性血小板减少性紫癜
- Author:
Li SHI
;
Haibao ZHU
;
Qiaoying LANG
- Publication Type:Journal Article
- Keywords:
Children;
Idiopathic thrombocytopenic purpura;
Gamma globulin;
Platelet parameters
- From:
China Pharmacist
2016;19(3):538-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the efficacy of gamma globulin at different doses combined with dexamethasone in the treatment of children with severe idiopathic thrombocytopenic purpura. Methods: Totally 96 cases of patients with idiopathic thrombocytopenic purpura were divided into group A ( standard high dose of gamma globulin+dexamethasone) , group B ( middle dose of gamma globulin+dexamethasone) and the control group ( dexamethasone) . The clinical effects and platelet parameters of the three groups were com-pared. Results:The levels of PLT, PCT and PDW in group A and group B after the treatment were higher than those in the control group(P<0. 05). The recovery time of normal platelet and the stop time of bleeding in group A and group B were lower than those in the control group(P<0. 05), and there was no significant difference between group A and group B(P>0. 05). The clinical effective rate of group A and group B was higher than that in the control group(P<0. 05), and there was no significant difference between group A and group B(P>0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P>0. 05). Conclusion:Gamma globulin at middle dose shows significant effect as at high dose in the patients with ITP, which can reduce the dosage and is worthy of clinical promotion.
