Preparation and Pharmacodynamics of Dual Anesthetic Remifentanil-Propofol Microemulsion
- VernacularTitle:双效麻醉药复方瑞芬太尼-丙泊酚微乳的制备及药效学评价
- Author:
Limin PAN
- Publication Type:Journal Article
- Keywords:
Remifentanil;
Propofol;
Microemulsion;
Dual anesthetic;
Anesthetic effects
- From:
China Pharmacist
2016;19(3):443-447
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare dual anesthetic remifentanil-propofol microemulsion ( Rem-Pro MM) and evaluate the anesthetic effects in adult dogs by continuous infusion. Methods:The Rem-Pro MM was prepared by the high pressure homogenization technolo-gy. The Rem-Pro MM was characterized with the particle size distribution, zeta potential and morphology as the indices. The anesthetic effects in adult dogs were evaluated by continuous infusion of Rem-Pro MM. Results:The particle size distribution, polydispersion in-dex and zeta potential of Rem-Pro MM was (217. 6 ± 48. 2) nm, (0. 212 ± 0. 032) and ( -31. 2 ± 3. 8) mV, respectively. The Rem-Pro MM was found to be small and homogeneous under a transmission electron microscope. The pharmacodynamic studies showed that the Rem-Pro MM in adult dogs with partial spleen surgery had promising anesthetic effects during the anesthesia induction and mainte-nance procedure. Conclusion: The dual anesthetic remifentanil-propofol microemulsion has good effects of sedation and analgesia, which is expected to be used in clinics.
