Pathogenesis and treatment progress of glucocorticoid-induced osteoporosis in children
10.3760/cma.j.issn.1673-4408.2016.05.005
- VernacularTitle:儿童糖皮质激素性骨质疏松的发病机制及诊治
- Author:
Haibo LIU
- Publication Type:Journal Article
- Keywords:
Glucocorticoid;
Nephrotic syndrome;
Osteoporosis;
Growth hormone;
Insulin-like growth factor;
Osteoprotegerin;
Parathyroid hormone
- From:
International Journal of Pediatrics
2016;43(5):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Currently osteoporosis in children has become an important disease, which includes primary osteoporosis and secondary osteoporosis.Glucocorticoid induced osteoporosis is the most common secondary osteoporosis.Glucocorticoid has been widely used in clinical treatment of various inflammatory diseases and autoimmune function disorders, such as nephrotic syndrome and systemic lupus erythematosus.Although glucocorticoid has strong anti-inflammatory, anti-allergic and immunosuppressive effect,long-term use can cause a variety of complications, such as osteoporosis.This review focuses on the pathogenesis of glucocorticoid induced osteoporosis and its diagnosis and treatment strategy,in order to provide more extensive theoretical basis for pediatricians, to draw more attention for them, and also to provide appropriate evaluation and clinical guide.
