Soft regulation of inflammatory immune responses
10.3969/j.issn.1001-1978.2016.03.001
- VernacularTitle:炎症免疫反应软调节
- Author:
Wei WEI
- Publication Type:Journal Article
- Keywords:
inflammatory immune responses ( IIR);
soft regu-lation of inflammatory immune responses ( SRIIR );
immune cells;
cytokines;
signal transduction;
discovery of new drugs
- From:
Chinese Pharmacological Bulletin
2016;32(3):297-303
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation reaction and immune response are in-separable in the levels of system, tissue, cell and molecule. In-flammatory immune responses ( IIR) is proposed in this paper, which is defined a moderate or abnormal system responses of in-flammatory immune related cells in responding to the internal and external environment changes of body. It is described briefly that the research progresses of inflammatory immune cells ( e. g. , macrophages, dendritic cells, T cells and B cells, etc. ) and non-inflammatory immune cells ( e. g. , glial cells, endothe-lial cells, epithelial cells, fibroblasts, synovial cells and liver cells, etc. ) , and cytokines/receptor signal transduction in-volved in IIR. Moreover, the existing problems about regulating IIR drugs clinically are summarized. It is firstly put forward that soft regulation of inflammatory immune responses ( SRIIR) is a new direction of discovery and development of new drugs for the treatment of IIR related diseases.
