Animal models of brain metastasis：preparation methods and research progress
10.3969/j.issn.1001-1978.2016.03.002
- VernacularTitle:脑转移瘤动物模型的制备方法及研究进展
- Author:
Baiping CUI
;
Ping CHEN
;
Anyang SUN
- Publication Type:Journal Article
- Keywords:
brain metastasis;
tumor;
animal models;
nude mice;
cell inoculation;
model preparation;
model evaluation
- From:
Chinese Pharmacological Bulletin
2016;32(3):304-309
- CountryChina
- Language:Chinese
-
Abstract:
Brain metastasis ( BM) is a common brain tumor in a-dults, originating from extracranial location in the body. There has been a growing interest in producing suitable animal models for studying BM in vivo. Current BM models take peripheral or brain route for tumor cell inoculation, including intra-cardiac or intra-carotid artery injection or orthotopic injection. Direct im-plantation of patient tumor biopsies into rodent brain bears ad-vantages of clinical relevance. This review presents a compre-hensive introduction to key elements for establishing animal mod-els of BM, with highlights on selections of suitable model ani-mals, brain-seeking tumor cell lines, reasonable inoculation routes, as well as succedent phenotyping methods. In the end, perspectives and future directions in this field are discussed.
