Evaluation the value of C13 breath test,serum pepsinogen and gastric cancer related tumor markers co-detection in health examination
10.3969/j.issn.1673-4130.2016.05.012
- VernacularTitle:C 13呼气试验、血清胃蛋白酶原及胃癌相关标志物联合检测对健康体检的价值
- Author:
Xuemei TIAN
;
Jia ZHAO
;
Guangyue YIN
- Publication Type:Journal Article
- Keywords:
gastric cancer;
pepsinogen;
tumor markers;
C13 breath test
- From:
International Journal of Laboratory Medicine
2016;37(5):608-610
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the distribution characteristics of serum pepsinogen (PG ) and gastric cancer related tumor markers in the healthy population ,and analyse their value in health examination .Methods The levels of serum tumor markers ,pep‐sinogenⅠ(PGⅠ ) and pepsinogenⅡ(PGⅡ) were detected in 958 subjects who underwent physical examination by using the Lumi‐nex 200 instrument ,and the ratio of PGⅠ /PGⅡ(PGR) was calculated .Meanwhile ,the C13 breath test was carried out ,and relation‐ships among these clinical indicators were analysed .Results In this population ,The serum level of PGⅠ in male subjects was high‐er than that in female subjects ,there was statistically significant difference(P<0 .05) .The levels of serum PGⅠ ,PGⅡ ,carcinoem‐bryonic antigen(CEA) ,carbohydrate antigen 199(CA199) and carbohydrate antigen 242(CA242) were gradually increased with age ,while the PGR was slowly decreased with age .The positive rate of C13 breath test in male subjects was higher than that in fe‐male subjects ,there was statistically significant difference(P<0 .05) .Compared with subjects whose C13 breath test results were negative ,the serum levels of PGⅠ and PGⅡ were higher ,while the PGR was lower in subjects whose C13 breath test results were positive(P<0 .05) .Conclusion The distribution of serum PG might be correlated with age ,gender and the infection of Helicobact‐er pylori in healthy population .It is shown that the effects of tumor markers on gastric cancer screening are limited .
