Relationship between plasminogen activator inhibitor-1 gene polymorphism and gastrointestinal bleeding in ;Henoch-Sch?nlein purpura

VernacularTitle:纤溶酶原激活物抑制因子1基因多态性与过敏性紫癜胃肠道出血的相关性
Author: Baoxiang WANG ; Hong MEI ; Hanming PENG ; Yuan GAO ; Chunhua YU ; Yan DING
Publication Type:Journal Article
Keywords: polymorphism; Henoch-Sch?nlein purpura; gastrointestinal bleeding; child
From: Journal of Clinical Pediatrics 2016;34(3):197-200
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship of single nucleotide polymorphism (4G/5G) in the promoter of plasminogen activator inhibitor-1 (PAI-1) and plasma PAI-1 level with gastrointestinal bleeding in Henoch-Sch?nlein purpura (HSP). Methods A total of 524 children with HSP in acute phase were recruited, and divided into gastrointestinal bleeding group (bleeding group, n?=?186) and non-gastrointestinal bleeding group (control group, n?=?338). The genotype frequency of 4G/5G polymorphism, the plasma PAI-1 level, and other parameters related to coagulation and ifbrinolysis were measured and compared between two groups. Results The levels of platelet count (PLT), platelet distribution width (PDW), serum D dimer (DD), serum PAI-1 were signiifcantly higher in the bleeding group than those in the control group, and the levels of mean platelet volume (MPV) and plasma ifbronectin protein of ifbrinogen (FIB) were signiifcantly lower in the bleeding group than those in the control group (P?