Research progress of the association between pro-inflammatory cytokines and osteoarthritis
10.11958/20150380
- VernacularTitle:促炎症因子与骨性关节炎关系的研究进展
- Author:
Bing LI
;
Jun LIU
;
Yu XIAO
;
Yanmin BU
;
Dan XING
- Publication Type:Journal Article
- Keywords:
osteoarthritis;
leptin;
vascular endothelial growth factors;
polyunsaturated alkamides;
S100 proteins;
re-view;
pro-inflammatory cytokinesre
- From:
Tianjin Medical Journal
2016;44(3):281-285
- CountryChina
- Language:Chinese
-
Abstract:
Osteoarthritis (OA) is the main reason of joint pain and dysfunction in the elderly in China, and its incidence is increasing year by year. In addition to the joint peripheral osteophyte formation and degeneration of articular cartilage, in?flammation, as one of the dominant pathological changes in OA, is causing more and more attention. Pro-inflammatory cyto?kines (PIC) are important mediators of inflammation. The increased level of PIC in OA can lead to systemic and local inflam?mation, results in further destruction of many kinds of tissues in joint (such as cartilage), and accelerates the development of OA. Besides, the severity of inflammation is closely related to the clinical symptoms of OA. Therefore, it is important to un?derstand the role of PIC in the pathogenesis of OA. From the perspective of the relationship between pro-inflammatory fac?tors and OA and the molecular mechanism, this article reviews the research progress in this field, which provides new con?cepts for diagnose and treatment of OA.
