Research progress of antiviral treatment in preventing mother-to-infant transmission of hepatitis B virus
10.11958/58999
- VernacularTitle:抗病毒药物阻断乙型肝炎母婴传播的研究进展
- Author:
Qian LIANG
;
Ni LI
;
Yanyan SUN
;
Shurong SONG
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
disease transmission,vertical;
antiviral agents;
Lamivudine;
mother-to-child trans-mission;
Telbivudine;
Tenofovir;
review
- From:
Tianjin Medical Journal
2016;44(3):381-384
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) infection is a worldwide health problem and vertical transmission is the main source of chronic infection in Asian countries. Breakthrough perinatal HBV transmission occurs in 10%-15% of infants born to pregnatal women with high viral load even with appropriate postexposure immunoprophylaxis. Management of chronic hepati?tis B (CHB) during pregnancy remains a challenge, with unique issues that involve prevention of mother-to-child transmis?sion (MTCT) and safe use of antiviral therapy. Previous studies indicate that antiviral therapy with analogs (Lamivudine, Tel?bivudine or Tenofovir) may prevent vertical transmission during late pregnancy in highly viremic mothers. This article sum?marized relevant studies that antiviral therapy in preventing MTCT of hepatitis B virus.
