The studying of fosinopril combined with fenofibrate on the preventing of diabetic retinopathy in diabetic mice
10.11958/59086
- VernacularTitle:福辛普利联合非诺贝特对糖尿病小鼠视网膜病变干预作用的研究
- Author:
Jinsong KUANG
;
Yurong ZHAO
;
Yuyan ZHAO
;
Ruoxi LI
;
Caihong XIN
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
diabetes complications;
oxidative stress;
apoptosis;
disease models,animal;
Fosino-pril;
Fenofibrate;
vascular endothelial growth factor
- From:
Tianjin Medical Journal
2016;44(3):322-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect and mechanism of the Fosinopril combined with Fenofibrate on the prevent?ing of diabetic retinopathy. Methods A total of 150 viripotent ICR mice(100 male mice, 50 female mice) were randomly di?vided into five groups(n=30), including A group (Sham group), B group (Model group), C group [Fosinopril prevented group, 20 mg/(kg·d)], D group [Fenofibrate prevented group, 400 mg/(kg·d)] and E group (Fosinopril combined with Fenofibrate pre?vented group). The expression levels of Bax and Bcl-2 gene mRNA were determined by RT-PCR method. TUNEL staining method was used to detect the apoptosisi of retinal cells. Results The Bcl-2 mRNA of A group, Bax mRNA of B group were higher than those of other four groups. Bcl-2 mRNA of E group was higher than that of C group and D group, while the Bax mRNA was lower than those of two groups(all P<0.05). The TUNEL index of B group was the highest than other groups, which of E group
