Advances in functions and mechanisms of long non-coding RNA MALAT-1 in tumors
10.3969/j.issn.1000-8179.2016.04.017
- VernacularTitle:长链非编码RNA MALAT-1在肿瘤中的作用及其机制研究进展
- Author:
Jinlong HUANG
;
Jianzhen SHEN
- Publication Type:Journal Article
- Keywords:
MALAT-1;
lncRNA;
tumor;
mechanism
- From:
Chinese Journal of Clinical Oncology
2016;43(4):161-165
- CountryChina
- Language:Chinese
-
Abstract:
Long non-coding RNAs (lncRNAs) have gradually become a research hotspot in recent years. The abnormal expression of some lncRNAs has been proven to promote tumorigenesis and progression. Among the lncRNAs, metastasis-associated lung adenocar-cinoma transcript 1 (MALAT-1) has attracted considerable attention in various tumor studies, particularly lung cancer. Therefore, the mechanism in which MALAT-1 regulates the cellular activities of tumors should be analyzed. This review mainly discusses the molecu-lar structure, biological function, and role of MALAT-1 in regulating cell proliferation, tumor metastasis, cell cycle, apoptosis, and so on. Furthermore, the role of MALAT-1 in epigenetic regulation is appropriately illustrated to provide a novel perspective in literature on the prevention and treatment of tumors.
