Clinical analysis of the microangiopathic hemolytic anemia and renal impairment secondary to methylmalonic ;academia in children
10.3969/j.issn.1000-3606.2016.03.015
- VernacularTitle:儿童继发于甲基丙二酸血症的微血管性溶血及肾脏损伤病例分析
- Author:
Chunzhen LI
;
Dongfeng ZHANG
;
Ling LIU
;
Kunfen LI
;
Lanlan GE
;
Jingxia WANG
- Publication Type:Journal Article
- Keywords:
mmethylmalonic academia;
microangiopathic hemolytic anemia;
renal impairment;
child
- From:
Journal of Clinical Pediatrics
2016;34(3):217-219
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To review the clinical features in children with methylmalonic academia (MMA) having the primary clinical manifestations of microangiopathic hemolytic anemia and renal impairment. Methods The clinical data of 4 children diagnosed of MMA with the primary clinical manifestations of microangiopathic hemolytic anemia and renal impairment were retrospectively analyzed from August 2013 to present. Results In the four children (two boys and two girls) with the age from nine months to three years seven mouths, two children were diagnosed with MMA combined with homocysteine, and 2 children were diagnosed with MMA, but there was no homocysteine testing. All four children showed moderate to severe anemia, proteinuria, hematuria, and hypertension. One child had abnormal renal function and thrombocytopenia, and manifested as hemolytic uremic syndrome. Renal biopsy was performed in 2 children and they had glomerular sclerosis lesions with renal tubular necrosis and mesangial proliferative glomerulonephritis respectively. All children were treated with vitamin B12, and the indexes of microangiopathic hemolytic anemia and renal impairment were improved signiifcantly. Conclusions MMA may be combined with microangiopathic hemolytic anemia, renal impairment and even hemolytic uremic syndrome, and the early diagnosis and treatment is required.
