The clinical features of patients with Parkinson's disease with chronic pain and its correlation with cognitive function
10.3760/cma.j.issn.1008-6706.2016.03.029
- VernacularTitle:帕金森病伴慢性疼痛的临床特征及其与认知功能的相关性研究
- Author:
Cuilan HUANG
;
Jingnan XIAO
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Chronic pain;
Clinical features;
Cognitive function;
The correlation
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(3):423-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical features of patients with Parkinson's disease (PD)with chronic pain and its correlation with cognitive function.Methods 100 PD patients with chronic pain were selected as the observa-tion group.100 PD patients without chronic pain were selected as disease control group.90 healthy subjects with pain were selected as control group.Statistical and clinical features of PD patients with pain,and the relationship between cognitive function were made.Results 100 patients with chronic pain with PD skeletal muscle pain in 42 cases (42.0%),motility pain in 23 cases (23.0%),23 cases of nerve root pain (23.0%),9 cases of central pain (9.0%),akathisia in 3 patients (3.0%);Control pain in patients with chronic pain with part mainly in the head and neck and the waist,PD patients with chronic pain with mainly in the limbs,pain in the two groups the incidence of head and neck pain,waist pain,limb pain had statistical differences (χ2 =10.017,4.990,21.770,all P <0.05);Observation group of daily life,emotion,ability to walk,normal work,sleep,life fun scores were better than those in control group,with statistical significance (t =7.021,7.011,3.167,7.016,7.014,8.036,all P <0.05);PD with pain group and PD without pain in gender,age,course of the disease symptoms,PD with pain group and PD without pain in UPDRS score,H -Y in installment,HAMD scores,PDQL score,LED aspects comparison was statistically significant (χ2 =5.307,4.880,all P <0.05),PD with pain group smell disorders,motion sickness were higher than the proportion of the PD without pain group,with statistical significance (t =-1.689,-1.561,all P <0.05);PD patients with pain group named ability score,delayed recall below PD without pain group,the difference was statistically significant (P <0.05),PD patients with pain and PD without pain group in the MoCA scores and other project score had no statistical significance (t =-0.967,-0.272,-0.791,-0.837,-0.671,-0.658,all P >0.05).Conclusion PD associated with chronic pain is given priority to with skeletal muscle pain,PD associated with chronic pain pain is different from normal people,PD associated with chronic pain has influence on daily life, sleep quality and depression of patients bad feelings,PD associated with chronic pain are closely related to the depres-sion and cognitive dysfunction of patients.Cognitive and emotional disorders may be involved in the pathogenesis of chronic pain.
