Epileptic seizures and electroencephalographic findings in patients of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes
10.3760/cma.j.jssn.1673-4904.2016.03.011
- VernacularTitle:线粒体脑肌病伴高乳酸血症及卒中样发作综合征患者癫痫发作临床特征分析
- Author:
Xiai YANG
;
Tao CHEN
;
Deshuai LI
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
MELAS syndrome;
Epilepsy;
Electroencephalography;
Retrospective studies
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the features of epileptic seizures and eletroencepalogram (EEG)in patients of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). Methods Fifty-five patients with MELAS were selected. EEG and head MRI was performed on all patients.The types of epileptic seizure and EEG changes were compared between patients in and outside stroke-like episodes. Results Epileptic seizures occurred in 49 of 55 patients (89.1%) with MELAS, while multitype epileptic seizures were presented in 33 cases(67.3%). The frequency of partial seizures, generalized tonic-clonic seizures, status epilepticus was 47.3%(26/55), 69.1%(38/55), 38.2%(21/55) in stroke-like episodes and12.7%(7/55), 27.3%(15/55), 5.5%(3/55) in nonstroke-like episodes, which had statistical significance (χ2 = 8.023, 10.647, 11.002; P=0.022, 0.016, 0.005, respectively). Abnormal EEGs appeared in all patients.The rates of slow alpha frequency, diffuseδorθwave, epileptic discharges were 7.3%(4/55), 43.6%(24/55) and 25.5%(14/55) in stroke-like episodes and 30.9%(17/55), 58.2%(32/55) and 23.6%(13/55) in nonstroke-like episodes, respectively.Slow alpha frequency was significantly different between patients in and outside stroke-like episodes (χ2=8.933, P=0.019). Conclusions Epileptic seizures with different types are more common during stroke-like episodes in patients with MELAS.While the rates of epileptic discharges are also common outside the stroke-like episodes.
