The correlation of uric acid level and the circadian rhythm of blood pressure in hypertensive patients
10.3760/cma.j.jssn.1673-4904.2016.03.014
- VernacularTitle:高血压患者昼夜血压节律与血清尿酸的相关性
- Author:
Hongkai XIAO
;
Chengzhe LAI
;
Siyu LIANG
;
Jialong LIN
;
Qinhong CAI
;
Rong ZOU
- Publication Type:Journal Article
- Keywords:
Uric acid;
Non-dipper hypertension;
Dipper hypertension
- From:
Chinese Journal of Postgraduates of Medicine
2016;39(3):238-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation of uric acid(UA) level and the circadian rhythm of blood pressure in hypertensive patients. Methods Among the individuals who presented to the cardiology clinic, 70 patients who had hypertension and were diagnozed with non- dipper hypertension (non-dipper hypertension group) by 24 h ambulatory blood pressure monitoring (ABPM), 70 patients with dipper hypertension patients (dipper hypertension group), and 52 normotensive individuals (control group) were enrolled in this study. Peripheral venous blood samples were collected from all the patients in order to evaluate the hematological and biochemical parameters. All the assessed parameters were compared among three groups. Results The level of UA in non-dipper hypertension group was the highest, in dipper hypertension group was higher and in contrl group was the lowerst:(393.57 ± 53.52), (280.57 ± 41.64), (267.66 ± 59.38) μmol/L, and there were significant differences (P<0.01). Multivariate Logistic regression analysis revealed that the level of UA was an independent risk factor for non-dipper circadian rhythm of blood pressure (P = 0.003, OR = 2.26, 95% CI: 1.34- 3.89). Conclusions The higher level of UA may be a risk factor for non-dipper circadian rhythm of blood pressure in hypertension patients.
