Research advancement of calcium phosphate and calcium sulfate scaffolds in bone tissue engineering
10.3969/j.issn.2095-4344.2016.08.021
- VernacularTitle:磷酸钙及硫酸钙支架在骨组织工程中的研究进展
- Author:
Zhida ZHANG
;
Xiaobing JIANG
;
Gengyang SHEN
;
Hui REN
;
Zhidong YANG
;
Jianchao CUI
;
Kang CHEN
;
Jingjing TANG
;
Ling MO
;
Shunxin LIN
;
De LIANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2016;20(8):1203-1209
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: It is a hotspot that calcium phosphate and calcium sulphate as the main ingredients are combined with one or more other materials to improve or increase the performance of bone tissue engineering scaffolds. OBJECTIVE: To introduce the research advance of these two kinds of scaffolds in bone tissue engineering. METHODS: The articles related to the bone tissue engineering published during January 2000 to June 2015 were retrieved from CNKI and PubMed databases by computer. The key words were “bone tissue engineering, scaffold, calcium phosphate, calcium sulphate, vascularization” in Chinese and English, respectively. ESULTS AND CONCLUSION: Calcium phosphate and calcium sulfate are characterized as having good biocompatibility, biodegradability, osteoconductivity and complete bone substitutability. However, single use of calcium phosphate or calcium sulfate scaffold has certain disadvantages, both of which are difficult to ful y meet the requirements of the bone defect repair. Improvement can be acquired in the mechanical strength, injectability and biodegradability, as wel as drug-loading and pro-angiogenesis of the scaffold in combination with other materials. In the basal and clinical research, we should explore and develop ideal scaffolds in on the basis of therapeutic aim. However, most of the scaffold studies are stil at the extracorporeal and animal experiment stage, and the comparative studies on composite scaffolds and optimal proportion of those composite scaffolds stil need to be further investigated.
