Research advances in selective adaptor protein autophagy of p62/sequestosome-1
10.3867/j.issn.1000-3002.2016.03.012
- VernacularTitle:选择性自噬接头蛋白p62/sequestosome 1的研究进展
- Author:
Yisi CHEN
;
Fuyong SONG
- Publication Type:Journal Article
- Keywords:
p62/sequestosome-1;
autophagy;
signaling pathway;
neurodegenerative diseases;
tumor
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(3):258-265
- CountryChina
- Language:Chinese
-
Abstract:
p62/sequestosome-1(SQSTM1)is an important selective autophagy adaptor protein, which contains six functional regions:ubiquitin-binding domain,Keap1 interacting region,LC3 interaction region,tumor necrosis factor receptor-associated factor 6 binding domain,Phox and Bem1p and ZZ-type zinc finger domain. p62/SQSTM1 plays an important role in the removal of ubiquitin proteins. It also regulates the signaling pathway of nuclear factor erythroid 2 related factor 2-antioxidant respose element, NF-κB and the caspase-8 mediated apoptosis. The abnormal expression of p62/SQSTM 8 is closely related to neurodegenerative diseases (such as Huntington disease,Alzheimer disease,Parkinson disease),cancer,infective diseases,genetic diseases and chronic diseases. So far many researchers have shed light on the structure function and mechanism of p62/SQSTM1. This paper reviews the role of p62/SQSTM1 in the metabolism of proteins,the regulation of multiple signaling pathways and in the occurrence of diseases in order to provide a new theoretical basis for the treatment of autophagy targets.
