Effect of curcumin on spinal cord injury repair via inhibiting NF-κB signalling pathway:research progress
10.3867/j.issn.1000-3002.2016.03.014
- VernacularTitle:姜黄素抑制NF-κB信号通路对脊髓损伤修复作用的研究进展
- Author:
Mengdan GAO
;
Jingquan LIN
;
Liang TONG
;
Jinyi ZHANG
;
Na HAN
;
Xuehong LIU
- Publication Type:Journal Article
- Keywords:
curcumin;
NF-κB signalling pathway;
spinal cord injury
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(3):272-277
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation response is the most crucial link in the pathogeneses of spinal cord injury (SCI),and is the basis of secondary damage. NF-κB Signalling pathway is activated excessively after SCI,so that numerous NF-κB possessing biological activities is quickly translocated into the nuclear and regulates the target genes,resulting in heightened inflammation and further tissue damage. Suppressing NF-κB signalling pathway and controlling inflammation response effectively are effective approaches to promoting SCI repair. It is found that curcumin has multiple target molecules to suppress NF-κB signalling pathway,block the excessive activation of NF-κB and reduce the expression of proinflammation cytokines,which plays an important role in SCI repair. This article discusses NF-κB signalling pathway,the contribution of NF-κB signalling pathway to SCI and the role of curcumins inhibition of NF-κB signalling pathway in SCI.
