Animal models of human prostate cancer lymphatic metastasis:a review
10.3867/j.issn.1000-3002.2016.03.015
- VernacularTitle:人前列腺癌淋巴转移动物模型的研究进展
- Author:
Shujiang ZHANG
;
Zuyue SUN
- Publication Type:Journal Article
- Keywords:
prostate cancer;
neoplasm metastasis;
lymphatic metastasis;
animal models;
stem cells
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(3):278-285
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is the most common cancer among males in the United states,and the incidence has risen dramatically in recent years in China. Lymph node metastasis is a strong predictor of the metastatic potential and poor outcome of prostate cancer. Animal models of human prostate cancer lymphatic metastasis can be used to study the pathogenesis and metastatic mechanisms of prostate cancer,and evaluate the efficacy of new drugs for lymphatic metastasis of prostate cancer. This paper reviews commonly-used animal models of human prostate cancer lymphatic metastasis,including xenograft mouse models,genetically engineered mouse models,rat models and canine models,analyzes their advantages and disadvantages,presents their functions and characteristics,introduces the applications of cancer stem cells in these models and test methods of these models,and highlights the main problems to be solved.
