Progress in treatment and study of renal toxicity by mercury poisoning
10.3867/j.issn.1000-3002.2016.03.016
- VernacularTitle:汞的肾毒性及治疗研究进展
- Author:
Zian CHEN
;
Zhiyong NIE
;
Wanhua LI
;
Pengyao HU
;
Xin SUI
;
Zewu QIU
;
Yongan WANG
- Publication Type:Journal Article
- Keywords:
mercury poisoning;
nephrotoxicity;
nephropathy
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(3):286-290
- CountryChina
- Language:Chinese
-
Abstract:
Mercury is one of the common heavy-metal toxins,which can cause damage throughout the body in a variety of ways. Cases of renal toxicity of mercury poisoning are increasing clinically. However,little is known about nephrotoxicity mechanisms,and treatment remains unsatisfactory. The mechanism of mercury toxic nephropathy is reviewed in this paper,including the direct toxic effect on the kidney,the injury to the biomembrane system,generation of Hg-metallothionein,imbalance of intra?cellular calciumion,oxidative damage,induced apoptosis,and immune injury. Besides,the mechanism and limitation of common therapies,potential developments of the field are discussed. This review will facilitate further investigations therapies about both the mechanism and treatment of mercury toxic nephropathy.
